NosA, a transcription factor important in Aspergillus fumigatus stress and developmental response, rescues the germination defect of a laeA deletion

► LaeA regulated transcription factors effect virulence and development downstream. ► NosA is negatively regulated by LaeA. ► The ΔlaeA germination defect is remediated in the double ΔnosA ΔlaeA mutant. ► ΔnosA has increased pathogenicity in the Galleria model of invasive aspergillosis. ► NosA is involved in resistance to menadione.