کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10954262 | 1097883 | 2007 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Kinase inhibitors for cardiovascular disease
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کلمات کلیدی
βARKcteNOSCaMKIIβ-ARsET-1ChFEPCsCa2+/calmodulin-dependent protein kinase II - Ca2 + / calmodulin وابسته پروتئین کیناز IICVDs - CVD هاadrenomedullin - آدرنومدولینAngiotensin II - آنژیوتانسین دوendothelin-1 - اندوتلین-1coronary artery disease - بیماری عروق کرونرCardiovascular diseases - بیماری قلبی-عروقی Ang II - دومEndothelial progenitor cells - سلول های پیش ساز اندوتلیالendothelial nitric oxide synthase - سنتاز اکسید نیتریک اندوتلیالCAD - طراحی به کمک رایانه یا کَدcongestive heart failure - نارسایی احتقانی قلبβ-adrenergic receptors - گیرنده های β-adrenergic
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Over the last decade, there has been substantial progress toward understanding the pathophysiology and treatment of cardiovascular diseases (CVDs). Elucidating cellular responses to the extracellular environment and signal transduction mechanisms have provided the opportunity to explore novel molecular therapeutic approaches for the treatment of CVDs. Neurohormonal stimulation has been implicated in these diseases; blockade of the renin-angiotensin and β-adrenergic systems are examples of therapeutic effectiveness. There are multiple cell signaling cascades, some of which are beneficial or compensatory and others deleterious. The balance between these pathways, which in large part is dictated by the cellular environment, determines the outcome as a diseased or non-diseased state. Selective targeting of signaling pathways using protein kinase inhibitors, would have a potential advantage over receptor blockers. We review potential protein kinase targets and recent evidence supporting therapeutic interventional value in CVDs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular and Cellular Cardiology - Volume 42, Issue 1, January 2007, Pages 1-11
Journal: Journal of Molecular and Cellular Cardiology - Volume 42, Issue 1, January 2007, Pages 1-11
نویسندگان
Rajesh Kumar, Vivek P. Singh, Kenneth M. Baker,