Stimulation of inflammatory gene expression in human preadipocytes by macrophage-conditioned medium: Upregulation of IL-6 production by macrophage-derived IL-1β

► Macrophage-conditioned medium modulates human preadipocyte gene expression. ► Inflammation, macrophage infiltration and lipid accumulation pathways are modified. ► NFkB and IL-1β are central nodes in the upregulation of inflammation genes. ► IL-1β plays a key role in stimulating preadipocyte IL-6 production.