کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10957677 | 1099600 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Associations between allelic polymorphism of the BMP Binding Endothelial Regulator and phenotypic variation of cattle
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
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چکیده انگلیسی
The BMP Binding Endothelial Regulator (BMPER) is an inhibitor of bone morphogenetic proteins (BMPs), which play fundamental roles in adipocyte differentiation, fat development and energy balance. The objectives of this study were to detect polymorphisms of BMPER gene in four indigenous Chinese cattle populations and to investigate their effects on body size traits. Initially, three SNPs, namely G100597A (SNP1), C105331A (SNP2), and G105521A (SNP3) and eight distinct haplotypes were identified. In a total of 12 SNP-SNP combinations, SNP2-SNP3 had a strong linkage in Qinchuan cattle. These four cattle populations belong to intermediate genetic diversity at three SNP loci except Shuxuan cattle population in SNP3. At SNP1, genotype AA was associated with an increased body size. For SNP2, the heterozygous genotype individuals had a greater rump length than those of two other homozygotic genotypes. At SNP3, individuals with GG genotype had smaller rump length and hip width. A total of seven haplotype combinations were detected in Qinchuan cattle population and association analysis results showed individuals with Haplotype combination 4/2 (AAA/CAA) had greater rump length than those with Hap3/1 and Hap3/3 (PÂ <Â 0.05). These results strongly suggest that bovine BMPER gene may be used as a genetic marker for cattle breeding.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Probes - Volume 29, Issue 6, December 2015, Pages 358-364
Journal: Molecular and Cellular Probes - Volume 29, Issue 6, December 2015, Pages 358-364
نویسندگان
Chunping Zhao, Linsheng Gui, Yaokun Li, Martin Plath, Linsen Zan,