Structural, biological, and pharmacological strategies for the inhibition of nerve growth factor

► NGF antagonism is the first novel class of pain therapeutic in the last 30 years. ► The structural biology of NGF, p75NTR, and TrkA are reviewed in the context pharmacological target development. ► This article highlights the current state of therapeutic strategies for the targeting of NGF antagonists. ► The review provides a resource to summarize our current understanding of neurotrophin/receptor related structural biology. ► The review provides a comprehensive resource to summarize all reported NGF antagonists.