Haloperidol-loaded polysorbate-coated polymeric nanocapsules decrease its adverse motor side effects and oxidative stress markers in rats

► Innovative approach using haloperidol-loaded polysorbate-coated nanocapsules containing fish oil core (H-NcFO). ► H-NcFO reduces adverse motor side effects in rats when compared to free haloperidol. ► H-NcFO decreases oxidative stress parameters in extrapyramidal brain regions of rats in relation to free haloperidol.