Prenatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin produces alterations in cortical neuron development and a long-term dysfunction of glutamate transmission in rat cerebral cortex

► Short- and long-term effects of prenatal TCDD exposure. ► Reduced cell viability and increased apoptosis in prenatally TCDD-exposed rats. ► Prenatal TCDD impairs cortical neuron development and glutamate transmission. ► Prenatal TCDD-induced alteration in glutamate signaling could underlie cognitive deficit.