Effects of acute and chronic treatment elicited by lamotrigine on behavior, energy metabolism, neurotrophins and signaling cascades in rats

► Behavioral and neurochemical effects of lamotrigine. ► Lamotrigine presents antidepressant-like effects in the forced swimming test. ► Lamotrigine increases BDNF, NGF and AKT levels. ► Lamotrigine decreases Bcl-2 and GSK-3. ► Lamotrigine alters energy metabolism.