کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10961943 | 1102323 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cytokine and chemokine expression profiles in response to Mycobacterium tuberculosis stimulation are altered in HIV-infected compared to HIV-uninfected subjects with active tuberculosis
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کلمات کلیدی
LTBITregMTBIGRAQFTATBinterferon gamma release assay - آزمایش آزادسازی گاما اینترفرونTuberculosis - بیماری سلROC curve analysis - تجزیه و تحلیل منحنی ROCRegulatory T cell - سلول T تنظیم کنندهCytokine - سیتوکینlatent TB infection - عفونت TB پنهانCo-infection - عفونت مشترکActive TB - فعال تیروئیدMycobacterium tuberculosis - مایکوباکتریوم توبرکلوزیسHIV - ویروس نقص ایمنی انسانی Quantiferon - کالیفرنChemokine - کموکاین یا کموکین
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Cytokine and chemokine expression profiles in response to Mycobacterium tuberculosis stimulation are altered in HIV-infected compared to HIV-uninfected subjects with active tuberculosis Cytokine and chemokine expression profiles in response to Mycobacterium tuberculosis stimulation are altered in HIV-infected compared to HIV-uninfected subjects with active tuberculosis](/preview/png/10961943.png)
چکیده انگلیسی
Mycobacterium tuberculosis (Mtb) infects nearly 2 million people annually and is the most common cause of death in HIV-infected individuals. Tuberculosis (TB) diagnostics cater to HIV-uninfected individuals in non-endemic countries, are expensive, slow, and lack sensitivity for those most affected. Patterns of soluble immune markers from Mtb-stimulated immune cells are not well defined in HIV co-infection. We assessed immune differences between HIV-infected and HIV-uninfected individuals with active TB utilizing IFNγ-based QuantiFERON®-TB Gold In-Tube (QFT) testing in Nairobi, Kenya. Excess QFT supernatants were used to measure cytokine and chemokine responses by a 17-plex bead array. Mtb/HIV co-infected participants were significantly less likely to be QFT+ (47.2% versus 84.2% in the HIV-uninfected group), and demonstrated lower expression of all cytokines except for IFNα2. Receiver operator characteristic analyses identified IL-1α as a potential marker of co-infection. Among HIV-infected individuals, CD4+ T cell count correlated weakly with the expression of several analytes. Co-expression analysis highlighted differences in immune profiles between the groups. These data suggest that there is a unique and detectable Mtb-specific immune response in co-infection. A better understanding of Mtb immunology can translate into much needed immunodiagnostics with enhanced sensitivity in HIV-infected individuals, facilitating their opportunity to obtain live-saving treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tuberculosis - Volume 95, Issue 5, September 2015, Pages 555-561
Journal: Tuberculosis - Volume 95, Issue 5, September 2015, Pages 555-561
نویسندگان
Jillian L.M. Waruk, Zipporah Machuki, Christine Mesa, Jennifer A. Juno, Omu Anzala, Meenu Sharma, T. Blake Ball, Julius Oyugi, Sandra Kiazyk,