کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10962000 1102326 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A review of preclinical animal models utilised for TB vaccine evaluation in the context of recent human efficacy data
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
A review of preclinical animal models utilised for TB vaccine evaluation in the context of recent human efficacy data
چکیده انگلیسی
There is an urgent need for an improved TB vaccine. Vaccine development is hindered by the lack of immune correlates and uncertain predictive value of preclinical animal models. As data become available from human efficacy trials, there is an opportunity to evaluate the predictive value of the criteria used to select candidate vaccines. Here we review the efficacy in animal models of the MVA85A candidate vaccine in light of recent human efficacy data and propose refinements to the preclinical models with the aim of increasing their predictive value for human efficacy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tuberculosis - Volume 94, Issue 2, March 2014, Pages 105-110
نویسندگان
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