کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10971483 | 1106473 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The avian heterophil
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
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چکیده انگلیسی
Heterophils play an indispensable role in the immune defense of the avian host. To accomplish this defense, heterophils use sophisticated mechanisms to both detect and destroy pathogenic microbes. Detection of pathogens through the toll-like receptors (TLR), FC and complement receptors, and other pathogen recognition receptors has been recently described for the avian heterophil. Upon detection of pathogens, the avian heterophil, through a network of intracellular signaling pathways and the release and response to cytokines and chemokines, responds using a repertoire of microbial killing mechanisms including production of an oxidative burst, cellular degranulation, and production of extracellular matrices of DNA and histones (HETs). In this review, the authors describe the recent advances in our understanding of the avian heterophil, its functions, receptors and signaling, identified antimicrobial products, cytokine and chemokine production, and some of the effects of genetic selection on heterophils and their functional characteristics.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental & Comparative Immunology - Volume 41, Issue 3, November 2013, Pages 334-340
Journal: Developmental & Comparative Immunology - Volume 41, Issue 3, November 2013, Pages 334-340
نویسندگان
Kenneth J. Genovese, Haiqi He, Christina L. Swaggerty, Michael H. Kogut,