کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10971493 1106473 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Infectious Bursal Disease: A complex host-pathogen interaction
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Infectious Bursal Disease: A complex host-pathogen interaction
چکیده انگلیسی
In the case of IBDV, immunosuppression is both a direct consequence of the infection of specific target immune cells and an indirect consequence of the interactions occurring in the immune network of the host. Recovery from disease or subclinical infection will be followed by immunosuppression with more serious consequences if the strain is very virulent and infection occurs early in life. Although the immunosuppression caused by IBDV is principally directed towards B-lymphocytes, an effect on cell-mediated immunity (CMI) has also been demonstrated therefore increasing the impact of IBDV on the immunocompetence of the chicken. In addition to its zootechnical impact and its role in the development of secondary infections, it may affect the immune response of the chicken to subsequent vaccinations, essential in all types of intensive farming. Recent progress in the field of avian immunology has allowed a better knowledge of the immunological mechanisms involved in the disease but also should give improved tools for the measurement of immunosuppression in the field situation. Although satisfactory protection may be provided by the induction of high neutralizing antibody titres, interference from parental antibodies with vaccination has become the most important obstacle in the establishment of control programs. In this context, recombinant HVT and immune complex vaccines show promising results.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental & Comparative Immunology - Volume 41, Issue 3, November 2013, Pages 429-438
نویسندگان
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