کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10971547 | 1106477 | 2015 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Signatures of resistance to Lepeophtheirus salmonis include a TH2-type response at the louse-salmon interface
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کلمات کلیدی
EctoparasiteMmpsAPCsDAMPAPPPAMPantigen-presenting cells - آنتیژن ارائه سلولApr - آوریلdamage-associated molecular pattern - الگوی مولکولی مرتبط با آسیبpathogen-associated molecular pattern - الگوی مولکولی وابسته به پاتوژنImmunohistochemistry - ایمونوهیستوشیمیGene expression - بیان ژنSalmon - ماهی سالمونLepeophtheirus salmonis - ماهی قزل آلا Lepeophtheirusalternatively activated macrophage - ماکروفاژ فعال متناوبclassically activated macrophage - ماکروفاژ کلاسیک فعالMatrix metalloproteinases - متالوپروتئیناز ماتریکسAcute-phase response - پاسخ فاز حادAcute-phase protein - پروتئین حاد فاز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Disease outbreaks with the salmon louse Lepeophtheirus salmonis cause significant economic losses in mariculture operations worldwide. Variable innate immune responses at the louse-attachment site contribute to differences in susceptibility among species such that members of Salmo spp. are more susceptible to infection than those of some Oncorhynchus spp. Relatively little is known about the mechanisms that contribute to disease resistance or susceptibility to L.âsalmonis in salmon. Here, we utilize histochemistry and transcriptomics in a comparative infection model with susceptible (Atlantic, sockeye) and resistant (coho) salmon. At least three cell populations (MHIIβ+, IL1β+, TNFα+) were activated in coho salmon skin during L.âsalmonis infection. Locally elevated expression of several pro-inflammatory mediators (e.g. IL1β, IL8, TNFα, COX2, C/EBPβ), and tissue repair enzymes (MMP9, MMP13) were detected in susceptible and resistant species. However, responses specific to coho salmon (e.g. IL4, IL6, TGFβ) or responses shared among susceptible salmon (e.g. SAP, TRF, Cath in Atlantic and sockeye salmon) provide evidence for species-specific pathways contributing to resistance or susceptibility, respectively. Our results confirm the importance of an early pro-inflammatory TH1-type pathway as an initial host response during infection with Pacific sea lice, and demonstrate subsequent regulatory TH2-type processes as candidate defense mechanisms in the skin of resistant coho salmon.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental & Comparative Immunology - Volume 48, Issue 1, January 2015, Pages 178-191
Journal: Developmental & Comparative Immunology - Volume 48, Issue 1, January 2015, Pages 178-191
نویسندگان
Laura M. Braden, Ben F. Koop, Simon R.M. Jones,