کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10971668 | 1106504 | 2011 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Individual sequence variability and functional activities of fibrinogen-related proteins (FREPs) in the Mediterranean mussel (Mytilus galloprovincialis) suggest ancient and complex immune recognition models in invertebrates
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کلمات کلیدی
ORFFREPFibrinogen-related proteinsMBL-associated serine proteasesMytilus galloprovincialisMASPsPAMPFicolinLTAMBLPRRsTLRs - TLR هاFREPs - آزادیEST - استlipoteichoic acid - اسید لیپتویکوئیکpathogen-associated molecular patterns - الگوهای مولکولی مرتبط با پاتوژنExpressed Sequence Tag - تکرار اظهار نظرopen reading frame - قاب خواندن بازMannose-binding lectin - لکتین اتصال دهنده مانوزMussel - مسیMAC - مکFibrinogen-related protein - پروتئین مرتبط با فیبرینوژنmembrane attack complex - پیچیده حمله غشاءpattern recognition receptors - گیرنده های تشخیص الگوToll-like receptors - گیرنده های پولی مانند
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Individual sequence variability and functional activities of fibrinogen-related proteins (FREPs) in the Mediterranean mussel (Mytilus galloprovincialis) suggest ancient and complex immune recognition models in invertebrates Individual sequence variability and functional activities of fibrinogen-related proteins (FREPs) in the Mediterranean mussel (Mytilus galloprovincialis) suggest ancient and complex immune recognition models in invertebrates](/preview/png/10971668.png)
چکیده انگلیسی
In this paper, we describe sequences of fibrinogen-related proteins (FREPs) in the Mediterranean mussel Mytilus galloprovincialis (MuFREPs) with the fibrinogen domain probably involved in the antigen recognition, but without the additional collagen-like domain of ficolins, molecules responsible for complement activation by the lectin pathway. Although they do not seem to be true or primive ficolins since the phylogenetic analysis are not conclusive enough, their expression is increased after bacterial infection or PAMPs treatment and they present opsonic activities similar to mammalian ficolins. The most remarkable aspect of these sequences was the existence of a very diverse set of FREP sequences among and within individuals (different mussels do not share any identical sequence) which parallels the extraordinary complexity of the immune system, suggesting the existence of a primitive system with a potential capacity to recognize and eliminate different kind of pathogens.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental & Comparative Immunology - Volume 35, Issue 3, March 2011, Pages 334-344
Journal: Developmental & Comparative Immunology - Volume 35, Issue 3, March 2011, Pages 334-344
نویسندگان
Alejandro Romero, Sonia Dios, Laura Poisa-Beiro, Maria M. Costa, David Posada, Antonio Figueras, Beatriz Novoa,