کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10971679 | 1106509 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mutations in an avian IgY-Fc fragment reveal the locations of monocyte Fc receptor binding sites
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Mutations in an avian IgY-Fc fragment reveal the locations of monocyte Fc receptor binding sites Mutations in an avian IgY-Fc fragment reveal the locations of monocyte Fc receptor binding sites](/preview/png/10971679.png)
چکیده انگلیسی
The avian IgY antibody isotype shares a common ancestor with both mammalian IgG and IgE and so provides a means to study the evolution of their structural and functional specialisations. Although both IgG and IgE bind to their leukocyte Fc receptors with 1:1 stoichiometry, IgY binds to CHIR-AB1, a receptor expressed in avian monocytes, with 2:1 stoichiometry. The mutagenesis data reported here explain the structural basis for this difference, mapping the CHIR-AB1 binding site to the CÏ
3/CÏ
4 interface and not the N-terminal region of CÏ
3 where, at equivalent locations, the IgG and IgE leukocyte Fc receptor binding sites lie. This finding, together with the phylogenetic relationship of the antibodies and their receptors, indicates that a substantial shift in the nature of Fc receptor binding occurred during the evolution of mammalian IgG and IgE.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental & Comparative Immunology - Volume 34, Issue 2, February 2010, Pages 97-101
Journal: Developmental & Comparative Immunology - Volume 34, Issue 2, February 2010, Pages 97-101
نویسندگان
Alexander I. Taylor, Brian J. Sutton, Rosaleen A. Calvert,