Insect tolerance to the crystal toxins Cry1Ac and Cry2Ab is mediated by the binding of monomeric toxin to lipophorin glycolipids causing oligomerization and sequestration reactions

► Monomers of Cry toxins bind to the gut glycolipid moiety. ► Cry toxins interact with lipid particles to form large cross-linked aggregates. ► Cry toxins are sequestered by cell-free coagulation reactions.