کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10972175 | 1106780 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Two molluscan BCL-2 family members from Manila clam, Ruditapes philippinarum: Molecular characterization and immune responses
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم آبزیان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Two molluscan BCL-2 family members from Manila clam, Ruditapes philippinarum: Molecular characterization and immune responses Two molluscan BCL-2 family members from Manila clam, Ruditapes philippinarum: Molecular characterization and immune responses](/preview/png/10972175.png)
چکیده انگلیسی
Apoptosis based immune responses are important component of host defense in mollusks. In this study, we have identified two novel molluscan BCL-2 cDNAs from Manila clam, Ruditapes philippinarum and named as RpBCL-2A and RpBCL-2B. There were four and three highly conserved BCL-2 homology (BH) regions in RpBCL-2A and RpBCL-2B, respectively suggesting these two genes could be different isoforms of anti-apoptotic BCL-2 family. Phylogenetic results revealed that Manila clam BCL-2 genes were clustered closely with invertebrate BCL-2 members. It gives evidence of their common origin and conserved features of invertebrate BCL-2 family. RpBCL-2A and 2B were expressed in tissue-specific manner showing the highest and lowest level of expression in gills and hemocytes, respectively. However there was no clear expression profile difference between two genes. After Vibrio tapetis challenge, transcriptional responses of RpBCL-2A and RpBCL-2B were induced in gills and hemocytes with high variation that could be due to effects of immune reactions of other host defense molecules.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fish & Shellfish Immunology - Volume 34, Issue 6, June 2013, Pages 1628-1634
Journal: Fish & Shellfish Immunology - Volume 34, Issue 6, June 2013, Pages 1628-1634
نویسندگان
Youngdeuk Lee, Ilson Whang, Sukkyoung Lee, Udeni Menike, Chulhong Oh, Do-Hyung Kang, Gang-Joon Heo, Jehee Lee, Mahanama De Zoysa,