کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11002029 | 1433778 | 2018 | 35 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antidepressants-related cardiovascular adverse events using the adverse event reporting system
ترجمه فارسی عنوان
عوارض جانبی قلبی عروقی مرتبط با داروهای ضد افسردگی با استفاده از سیستم گزارشدهی عوارض جانبی
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کلمات کلیدی
داروهای ضد افسردگی، عوارض جانبی، اختلالات قلب و عروق،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
The aim of this study was to evaluate clinical manifestations and the age and sex distribution of cardiovascular adverse events (CVAEs) related to antidepressants. The FDA Adverse Event Reporting System (FAERS) and Korea Adverse Event Reporting System (KAERS) database records on patients prescribed antidepressants were used. The frequency of CVAEs was compared between adults (19-64 years) and an older (ageâ¯â¥â¯65 years) group. In total, 75,608 CVAEs from 43,824 patients and 325 CVAEs from 313 patients in FAERS and KAERS, respectively, were included in the analysis. Among them, 7066 (16.08%) and 103 (32.91%) patients were 65 years of age or older in FAERS and KAERS, respectively. Serious AEs were significantly more common among older patients compared to adults in both the FAERS and KAERS datasets. CVAEs were frequently reported with paroxetine and duloxetine in the FAERS, while amitriptyline and duloxetine were reported in the KAERS. The two most frequent CVAEs were “ventricular arrhythmias and cardiac arrest” and “rate and rhythm disorders” in the FAERS, while “hypotension”, and “oedema”, were found in the KAERS. Several CVAEs were detected by the reporting odds ratios and proportional reporting ratios methods. The serious AEs associated with antidepressants might have a significant impact on older patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research - Volume 268, October 2018, Pages 441-446
Journal: Psychiatry Research - Volume 268, October 2018, Pages 441-446
نویسندگان
Yoon Kyong Lee, Jung Su Shin, Youngwon Kim, Jae Hyun Kim, Yun-Kyoung Song, Jung Mi Oh, In-Wha Kim,