کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1101313 953563 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Use of the Quadrivalent Human Papillomavirus Vaccine (Gardasil) as Adjuvant Therapy in the Treatment of Recurrent Respiratory Papilloma
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری های گوش و جراحی پلاستیک صورت
پیش نمایش صفحه اول مقاله
The Use of the Quadrivalent Human Papillomavirus Vaccine (Gardasil) as Adjuvant Therapy in the Treatment of Recurrent Respiratory Papilloma
چکیده انگلیسی

SummaryObjectiveTo examine the effect of the quadrivalent human papillomavirus vaccine, Gardasil, on the disease course of patients with recurrent respiratory papillomatosis (RRP).MethodsA retrospective chart review of patients with RRP was conducted and 20 patients were selected who had received the Gardasil vaccine as part of their treatment. Efficacy was assessed by calculating the intersurgical interval (ISI) before and after receiving the vaccine, as well as number of complete and partial remissions.ResultsAnalysis of all patients found a significant increase in the ISI of 3.1 months (95% confidence interval [CI]: 1.02–5.19, P = 0.0061). Male patients experienced an increase in the ISI of 4.2 months (95% CI: 1.6–6.7, P = 0.0048). Female patients had a nonsignificant increase in ISI of 1.2 months (95% CI: 3.1–5.4, P = 0.51). Eight patients (40%; six male and two female) experienced complete remission. Five patients (25%) overall (three male and two female) experienced partial remission. In total, complete or partial remission was achieved in a total of 13 (65%) patients (nine male and four female).ConclusionsThe Gardasil vaccine can modulate the severity of RRP and induce remission in some patients. The effect was much greater in males and in females in low estrogen states.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Voice - Volume 29, Issue 2, March 2015, Pages 223–229
نویسندگان
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