کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11022666 | 1701473 | 2018 | 24 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Divergent evolution and clade-specific duplications of the Insulin-like Receptor in malacostracan crustaceans
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کلمات کلیدی
IGFILPaGHInsulin-like androgenic gland hormoneIISIGFBPIAGSexual differentiation - تمایز جنسیTyrosine kinase - تیروزین کینازCrustaceans - خشخاشInsulin-like growth factor - فاکتور رشد مانند انسولینPhylogeny - فیلوژنیGene duplication - مضاعف سازی ژن، تکثیر ژنAndrogenic gland hormone - هورمون غده آندروژنیIGF binding protein - پروتئین اتصال دهنده IGFInsulin-like peptide - پپتید مشابه انسولینInsulin-like receptor - گیرنده انسولین مانند
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The Insulin-like Receptors (IRs) are an important protein family, represented by three members in vertebrates, two of which are well-known for their implication in metabolism (Insulin Receptor) and growth (IGF Receptor). In contrast, little is known about these receptors in invertebrates, in which a single gene generally exists except for a part of insects and other occasional species-specific duplications. In this study, we used publicly available sequences as well as de novo assembled transcriptomes to investigate the IR evolution in malacostracan crustaceans, animals in which the Insulin/IGF pathway is known to be implicated in sexual development through the androgenic gland hormone. We described the evolutionary divergence of malacostracan IRs compared to all the other metazoan sequences, including other pancrustaceans. We also demonstrated two well conserved duplications of IRs: one specific to the whole malacostracan class, another one specific to the decapod order. The potential implications for malacostracan biology are discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: General and Comparative Endocrinology - Volume 268, 1 November 2018, Pages 34-39
Journal: General and Comparative Endocrinology - Volume 268, 1 November 2018, Pages 34-39
نویسندگان
Herran Benjamin, Bertaux Joanne, Grève Pierre,