کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11023042 | 1701348 | 2018 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Oxidative stress and hepatotoxicity of Rana chensinensis exposed to low doses of octylphenol
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Oxidative stress and hepatotoxicity of Rana chensinensis exposed to low doses of octylphenol Oxidative stress and hepatotoxicity of Rana chensinensis exposed to low doses of octylphenol](/preview/png/11023042.png)
چکیده انگلیسی
This study investigated the effects of low doses of octylphenol (OP) on the oxidative stress and hepatotoxicity in amphibian liver. The frog, Rana chensinensis, were exposed to 10â8, 10â7, 10â6 mol/L OP for 10, 20 and 30 days. The activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) in liver were reduced at first, then recovered slightly, and the content of malondialdehyde (MDA) and hydrogen peroxide (H2O2) were increased significantly. Histopathology showed that in some liver tissues of OP treated frogs, the hematococoel expansion, the fat accumulation, the cytoplasmic vacuolization and even hepatocyte necrosis were present. Ultrastructure revealed that there were lipid droplet accumulation, mitochondria deformation and nuclear condensation in some hepatocytes. These results confirm that low doses OP exposure can give rise to oxidative stress in the liver of frogs, reduce antioxidant enzymes activities, lead to partial organelles damage in hepatocyte and the fat accumulate in hepatic tissue.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 64, December 2018, Pages 86-93
Journal: Environmental Toxicology and Pharmacology - Volume 64, December 2018, Pages 86-93
نویسندگان
Xin-yi Li, Fang Wei, Jin-shu Gao, Hong-yuan Wang, Yu-hui Zhang,