کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11023644 | 1701256 | 2018 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Optimized PID controller for an industrial biological fermentation process
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
تکنولوژی و شیمی فرآیندی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Vaccine development comprises multiple stages, the first of which involves cultivating an organism in a microbial fermenter to produce a vaccine product. In order to ensure the optimal synthesis of the vaccine product, it is necessary to maintain adequate control of the dissolved oxygen (dO2), which is required for the organism to grow and survive. Our work is concerned with controlling the dissolved oxygen in a biological fermenter using a PID (Proportional-Integral-Derivative) Controller. The product from this fermenter is used to create the immunization for a medical illness. However, the present configuration of the PID Controller is inadequate for maintaining the dissolved oxygen at the desired level of 35% relative to saturation. This inadequacy results in violent dO2 oscillations which compromise the quality of the product. To solve this issue, we use open-loop experimental data to develop empirical transfer-function models of the control process for dissolved oxygen. Then, we apply an optimization algorithm for the PID Controller to obtain the proportional, integral, and derivative gains that would best regulate the dissolved oxygen in the fermenter. The parameters obtained from this algorithm are applied experimentally to the biological fermenter set-up and the results are used to demonstrate that the PID optimization algorithm provides controller settings which successfully regulate the dissolved oxygen.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Process Control - Volume 71, November 2018, Pages 75-89
Journal: Journal of Process Control - Volume 71, November 2018, Pages 75-89
نویسندگان
Omar Khan, Chandra Mouli R. Madhuranthakam, Peter Douglas, Heron Lau, Jacob Sun, Patrick Farrell,