Intonation and Speech Rate in Parkinson's Disease: General and Dynamic Aspects and Responsiveness to Levodopa Admission

SummaryObjectiveThe aim of our study was the analysis of fundamental frequency (F0) variability (fundamental frequency standard deviation [F0SD]) and net speech rate (NSR) in the course of reading in Parkinsonian patients' speech, with special emphasis on the changes of F0SD and NSR from the first to the last sentence of the task.Patients and MethodsWe examined 138 patients with Parkinson's disease (PD) and 50 age-matched control persons using a standardized reading task with subsequent acoustical analysis of F0SD and NSR. A subgroup of 20 PD patients underwent a standardized levodopa challenge.ResultsF0SD in PD patients was significantly reduced compared with the control group when based on the measurement of the entire reading task. Furthermore, in the PD group, NSR and F0SD showed significant changes from the first to the last sentence of the reading task, but no correlation was seen between NSR and F0SD. Standardized levodopa administration had no effect on NSR and F0SD when related to the entire reading passage, but the aforementioned decline of F0 variability in the course of reading seemed to be counterbalanced by levodopa administration.ConclusionsIn this large series of PD patients, previous findings of reduced F0SD in PD were confirmed. Additionally, this is the first analysis to show an increasing reduction of F0 variability in the course of reading mirroring abnormalities in the dynamical aspects of speech in PD. According to the results of the levodopa challenge, dopaminergic stimulation seems to ameliorate dynamic intonation changes over time, whereas overall intonation variability might be a PD symptom independent of dopaminergic control.