کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11025219 | 1701010 | 2018 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Glutamate-Glutamine Transfer and Chronic Stress-Induced Sex Differences in Cocaine Responses
ترجمه فارسی عنوان
انتقال گلوتامات گلوتامین و اختلالات جنسی ناشی از استرس مزمن در پاسخهای کوکائین
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کلمات کلیدی
GLT-1DABGLNPFCCSDSVGLUT1NACHRPPAGSubstance use disorders - اختلالات مصرف موادchronic social defeat stress - استرس شکست مزمن اجتماعیMajor depression - افسردگی شدیدmit - باSex difference - تفاوت جنسیSUD - جنوبیdiaminobenzidine - دیامینو بنزیدینcyt - سیتCytosol - سیتوزولPlasma membrane - غشای پلاسماprefrontal cortex - قشر prefrontalMitochondria - میتوکندریاMitochondrion - میتوکندریونNucleus accumbens - هسته accumbensPresynaptic terminals - پایانه های پیشینپتیکHorseradish peroxidase - پراکسیداز هوررادیشCocaine - کوکائین Glu - گلوglutamate - گلوتاماتglutamate transporter-1 - گلوتامات transporter-1glutamine - گلوتامینphosphate-activated glutaminase - گلوتامیناز فعال فسفات
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Substance use disorders (SUD) often co-occur with other mental disorders such as major depression (MD). Our previous findings revealed sex-dependent changes in extracellular levels of glutamate (Glu) and glutamine (Gln) in the nucleus accumbens (NAc) in Long-Evans rats that were exposed to 21â¯days of chronic social defeat stress (CSDS), which models MD. The current study investigated the role of a Gln transporter called sodium-coupled neutral amino acid transporter subtype 1/2 (SNAT 1/2), phosphate-activated glutaminase (PAG), and astrocytic glutamate transporter-1 (GLT-1) on CSDS animals exposed to cocaine. Before cocaine exposure, CSDS males already showed decreased levels of SNAT 1/2 in the NAc and prefrontal cortex (PFC) compared to non-CSDS controls. The reduction in SNAT 1/2 levels was associated with an increase in Gln localization in the mitochondrial outer membrane in accumbal glutamatergic nerve terminals projecting from the PFC. CSDS females showed increased GLT-1 levels in the NAc and PFC compared to non-CSDS controls. Both acute and repeated cocaine exposure attenuated locomotor responses in CSDS males but increased those in CSDS females. Cocaine reduced SNAT 1/2 levels in the NAc but increased them in the PFC in CSDS males. Additionally, both PAG and GLT-1 levels were increased in the PFC in CSDS males. On the other hand, cocaine reduced SNAT 1/2 and GLT-1 levels in the NAc and PFC in CSDS females. Our results show that CSDS altered locomotor responses upon cocaine exposure in a sex-dependent manner that may be mediated by molecules associated with the Glu-Gln transfer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 391, 1 November 2018, Pages 104-119
Journal: Neuroscience - Volume 391, 1 November 2018, Pages 104-119
نویسندگان
Akiko Shimamoto, Virginie Rappeneau, Havisha Munjal, Tonie Farris, Christopher Davis, Alicia Wilson, Malcolm Edwards, Cindy Moore, Collin Reynolds, Charles K. Meshul,