کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11026101 | 1666434 | 2018 | 23 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Structural characterization and anti-thrombotic properties of fucoidan from Nemacystus decipiens
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Structural characterization and anti-thrombotic properties of fucoidan from Nemacystus decipiens Structural characterization and anti-thrombotic properties of fucoidan from Nemacystus decipiens](/preview/png/11026101.png)
چکیده انگلیسی
The sulfated polysaccharide NP2 was isolated and purified from Nemacystus decipiens, the structure and antithrombotic activity of NP2 was further studied. NP2 was composed of fucose, glucuronic acid, galactose and xylose at molar ratios of 76.3:20.5:1.5:1.7. ES-CID-MS/MS results showed that NP2 had a backbone of α (1â¯ââ¯3)-linked fucose and a branch was composed of Fuc-(2â¯ââ¯1)-GlcA, which was agree with the results of NMR and methylation analysis. The results also show that the sulfate groups were substituted at the C2 or C4 positions of the fucose residues. In addition, analysis of the antithrombotic activity results indicated that NP2 can increase the percentage of t-PA/PAI-1, thereby suggesting that NP2 has high fibrinolytic activity and should be explored as a novel antithrombotic agent.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 120, Part B, December 2018, Pages 1817-1822
Journal: International Journal of Biological Macromolecules - Volume 120, Part B, December 2018, Pages 1817-1822
نویسندگان
Kaiyun Cui, Wenjing Tai, Xindi Shan, Jiejie Hao, Guoyun Li, Guangli Yu,