کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
11026862 1666346 2019 39 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Human adipose-derived stem cells loaded with drug-coated magnetic nanoparticles for in-vitro tumor cells targeting
ترجمه فارسی عنوان
سلول های بنیادی مبتنی بر چربی انسان که با نانوذرات مغناطیسی مغناطیسی پوشش داده شده برای سلول های توموری درون سلولی قرار می گیرند
کلمات کلیدی
نانوذرات مغناطیسی کارکردی دارویی، سلول های بنیادی حاصل از چربی، سلول های استئوسارکوم، تحویل مداخله سلولی،
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
چکیده انگلیسی
In the present study we report about an in vitro model of adipose-derived stem cells (ADSCs) loaded with palmitate-coated MNPs (MNPsPA) as antitumor drug carriers targeting a 3D tissue-like osteosarcoma cells. Cell viability, MNPsPA-drug loading capacity, cell speed, drug release rate, magnetization and zeta potential were determined and analysed. The results revealed that ADSCs loaded with MNPsPA-drug complexes retained their viability at relatively high drug concentrations (up to 1.22 pg antitumor drug/cell for 100% cell viability) and displayed higher speed compared to the targeted tumor cells in vitro. The magnetization of the sterilized MNPsPA complexes was 67 emu/g within a magnetic field corresponding to induction values of clinical MRI devices. ADSCs payload was around 9 pg magnetic material/cell, with an uptake rate of 6.25 fg magnetic material/min/cell. The presented model is a proof-of-concept platform for stem cells-mediated MNPs-drug delivery to solid tumors that could be further correlated with MRI tracking and magnetic hyperthermia for theranostic applications.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 94, 1 January 2019, Pages 666-676
نویسندگان
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