کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11027415 | 1666296 | 2019 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
An integrated, accurate, rapid, and economical handheld consumer gluten detector
ترجمه فارسی عنوان
یک آشکارساز گلوتن دستی دستی، یکپارچه، دقیق، سریع و اقتصادی است
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کلمات کلیدی
سنسور گلوتن قابل حمل امنیت غذایی مصرف کننده، بیماری سلیاک، حساسیت گلوتن،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Celiac disease, characterized by autoimmune reactions to dietary gluten, affects up to 3 million in the US and approximately 0.5%-1% globally. A strict, lifelong gluten-free diet is the only treatment. An economic, simple, accurate, rapid and portable gluten testing device would enable gluten-sensitive individuals to safeguard their food safety. We developed a novel solution, Nimaâ¢, a gluten sensor that integrates food processing, gluten detection, result interpretation and data transmission in a portable device, detecting gluten proteins at or below the accepted 20â¯ppm threshold. We developed specific monoclonal antibodies, an optimized lateral flow immunoassay strip, and one-step aqueous extraction. Compared with reference R5, NimaTM antibodies (13F6 and 14G11) had 35- and 6.6-fold higher gliadin affinities, respectively. We demonstrated device performance using a comprehensive list of foods, assessing detection sensitivity, reproducibility, and cross-reactivity. Nima⢠presented a 99.0% true positive rate, with a 95% confidence interval of 97.8%-100%.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Chemistry - Volume 275, 1 March 2019, Pages 446-456
Journal: Food Chemistry - Volume 275, 1 March 2019, Pages 446-456
نویسندگان
Jingqing Zhang, Steven Barbosa Portela, Joseph Benjamin Horrell, Alex Leung, Dane Rene Weitmann, John Boguslaw Artiuch, Stephen Michael Wilson, Monica Cipriani, Lyndsie Katherine Slakey, Aquanette Michele Burt, Francisco Javier Dias Lourenco,