کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
11030463 1646304 2018 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Kidney damage induced by sub-chronic fine particulate matter exposure
ترجمه فارسی عنوان
آسیب کلیه ناشی از قرار گرفتن در معرض ذرات ریز ذرات مزمن
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
چکیده انگلیسی
According to the WHO, about 3 million people die each year due to ambient air pollution. Most of the in vivo studies on the PM2.5 effects have been done on respiratory and cardiovascular tissues. However, little is known about the effects on the tissues involved on xenobiotic removal, such as kidneys. In the present study we assess the harmful effects of sub-chronic exposure to PM2.5 on the kidney, by investigating histologic and serum alterations in healthy and hypertensive rat models. Mean PM2.5 concentrations during exposures were slightly above the daily WHO standard. Exposed animals showed fibrosis, mesangial expansion, decrease glomerular and tubular lumen volumes in kidneys, with an elevated BUN. Hypertensive animals also exhibited much more severe alterations than healthy animals. We conclude that PM2.5 induces minimal or small-scale abnormalities that can be determinant for renal health preservation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environment International - Volume 121, Part 1, December 2018, Pages 635-642
نویسندگان
, , , , ,