Synthesis and biological evaluation of substituted 3-(2′-benzimidazolyl)coumarin platinum(II) complexes as new telomerase inhibitors

Eight new platinum(II) complexes Pt1-Pt8 with substituted 3‑(2′‑benzimidazolyl) coumarins were synthesized and characterized. Pt1 is a telomerase inhibitor targeting c-myc promoter elements and causes mitochondrial dysfunction in the following order: Pt1 > Pt2 > Pt3.276