کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
11033015 | 1642812 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
(De)constructing the blastocyst: Lessons in self-organization from the mouse
ترجمه فارسی عنوان
(د) ساخت بلستوسیست: درس های خود سازمان از ماوس
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی کامپیوتر
علوم کامپیوتر (عمومی)
چکیده انگلیسی
Mammalian pre-implantation development - from the zygote to the blastocyst - offers a simple, tractable model for investigating how cell fate specification is coordinated across a population, and how it is integrated with morphogenetic events, at single-cell resolution. Mouse zygotes cultured ex utero in the absence of extrinsic factors readily develop to the blastocyst stage, mimicking events taking place in utero. This remarkable feature of the earliest stages of mammalian development represents a paradigm of an evolutionarily-conserved program of self-organization. At the centre of this self-organizing ability lies an extraordinarily labile developmental program, which can sense and respond to perturbations. To date, the blastocyst is also the only embryonic stage and of any species, from which stem cells representing each of its constituent lineages can be captured and propagated in vitro. Gaining insights into the mechanistic underpinnings of blastocyst development underscores our understanding of the inherent flexibility and robustness in the intrinsic developmental program in vivo, and underscores methods to recapitulate it in vitro.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Systems Biology - Volume 11, October 2018, Pages 98-106
Journal: Current Opinion in Systems Biology - Volume 11, October 2018, Pages 98-106
نویسندگان
Berenika Plusa, Anna-Katerina Hadjantonakis,