Les cytokines des plaquettes et leurs effets lors des transfusions de concentrés de plaquettes

In this state of the art review, we will present arguments on the role of platelet secretory products in modulating cellular parameters of immunity, and - very likely - in altering functions of those immune cells upon encounters while infusing platelets in blood recipients. We aimed at summarizing data that have been made available on the issue of cytokines/chemokines released by stored platelets prior to delivery. We will focus on the suspected role of the CD40/CD40L tandem in postplatelet transfusion reactions or incidents. We will present recent data on the role of pathogen inactivators on the docking and/or release of cytokines/chemokines by platelets.