کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1148433 957834 2008 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Several biplot methods applied to gene expression data
موضوعات مرتبط
مهندسی و علوم پایه ریاضیات ریاضیات کاربردی
پیش نمایش صفحه اول مقاله
Several biplot methods applied to gene expression data
چکیده انگلیسی

DNA microarray experiments result in enormous amount of data, which need careful interpretation. Biplot approaches show simultaneous display of genes and samples in low-dimensional graphs and thus can be used to represent the relationships between genes and samples. There are several different types of biplots, and these methods need to be evaluated because each plot provides different result.In this paper, we review several variants of biplot methods such as principal component analysis biplot, factor analysis biplot, multidimensional scaling biplot and correspondence analysis biplot. We investigate the properties of these methods and compare their performances by analyzing various types of well-known gene expression data. We also suggest the supplementary data method as a tool for (i) classifying the previously unknown sample/gene to existing class, (ii) analyzing mixture data and (iii) presenting illustrative variables, etc. The usefulness of this approach for interpreting microarray data is demonstrated.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Statistical Planning and Inference - Volume 138, Issue 2, 1 February 2008, Pages 500–515
نویسندگان
, , , ,