کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
11614 749 2006 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Osteoblast adhesion and matrix mineralization on sol–gel-derived titanium oxide
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Osteoblast adhesion and matrix mineralization on sol–gel-derived titanium oxide
چکیده انگلیسی

The biological events occurring at the bone–implant interface are influenced by the topography, chemistry and wettability of the implant surface. The surface properties of titanium alloy prepared by either surface sol–gel processing (SSP), or by passivation with nitric acid, were investigated systematically using X-ray photoelectron spectroscopy, scanning electron microscopy, atomic force microscopy and contact angle metrology. The bioreactivity of the substrates was assessed by evaluating MC3T3-E1 osteoblastic cell adhesion, as well as by in vitro formation of mineralized matrix. Surface analysis of sol–gel-derived oxide on Ti6Al4 V substrates showed a predominantly titanium dioxide (TiO2) composition with abundant hydroxyl groups. The surface was highly wettable, rougher and more porous compared to that of the passivated substrate. Significantly more cells adhered to the sol–gel-coated surface, as compared with passivated surfaces, at 1 and 24 h following cell seeding, and a markedly greater number of mineralized nodules were observed on sol–gel coatings. Collectively our results show that the surface properties of titanium alloy can be modified by SSP to enhance the bioreactivity of this biomaterial.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 27, Issue 10, April 2006, Pages 2201–2212
نویسندگان
, , , , , ,