Cellulose membranes are more effective in holding back vital proteins and exhibit less interaction with plasma proteins during hemodialysis

► Intermittent hemodialysis is a form of renal replacement therapy. ► Clinicians prefer to use synthetic dialyzers because of the efficient removal of uremic toxins. ► Our data revealed strong interaction of synthetic dialyzer materials with plasma proteins ► This interaction results in plasma protein removal and membrane occlusion.