کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1179323 962769 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Flexible ligand–flexible protein docking in protein kinase systems
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Flexible ligand–flexible protein docking in protein kinase systems
چکیده انگلیسی

Quite a few reviews on molecular docking have already appeared. This mini-review focuses on methods that incorporate protein flexibility in docking rather than those that treat protein targets as rigid molecules. This is still a challenging problem but there are encouraging recent advances. These methods will be reviewed particularly in light of their applications to protein kinases and phosphatases. In addition to obtaining correct docking pose, recent developments on exploring docking pathways are also highlighted.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics - Volume 1784, Issue 1, January 2008, Pages 244–251
نویسندگان
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