کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1184018 | 1491808 | 2013 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Protein expression profiles of chemo-resistant mixed phenotype liver tumors using laser microdissection and LC–MS/MS proteomics
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
Hepatocellular carcinoma (HCC) treated with trans-arterial chemoembolization (TACE) can later show areas of hepatocellular or cholangiocarcinoma (CC) differentiation. Biomarkers are required to define details in phenotype/pathogenesis of these HCC/CC regions, and similarities to their normal and classic counterparts. Proteins from laser microdissected FFPE tissue were in-gel digested and peptides analyzed by nano-HPLC–MS/MS. We identified 95 proteins with significant differential expression between HCC vs. CC regions. We also found significant differences in other tissue type comparisons. Some protein biomarkers are being reported here for the first time in the context of liver carcinogenesis and may be clinically useful.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: EuPA Open Proteomics - Volume 1, 2013, Pages 38–47
Journal: EuPA Open Proteomics - Volume 1, 2013, Pages 38–47
نویسندگان
Yoh Zen, David Britton, Vikram Mitra, Andrew Brand, Stephan Jung, Christopher Loessner, Malcolm Ward, Ian Pike, Nigel Heaton, Alberto Quaglia,