Solubility and thermodynamic function of vanillin in ten different environmentally benign solvents

• Solubility of vanillin in various environmentally benign solvents was measured.
• Good correlation was existed between experimental and calculated solubility data.
• Vanillin was found to be freely soluble in most of the solvents.
• The dissolution was observed as endothermic, spontaneous and entropy driven.

The solubility of vanillin in ten different environmentally benign solvents namely water, ethanol, ethylene glycol (EG), ethyl acetate (EA), isopropanol (IPA), propylene glycol (PG), polyethylene glycol-400 (PEG-400), Transcutol, butanol-1 and butanol-2 was measured and correlated at T = (298–318) K. The resulting experimental data were correlated with the modified Apelblat and Van’t Hoff models. Both the models showed good correlation of experimental solubility data with calculated ones with root mean square deviations in the range of (0.08–1.55) %. The mole fraction solubility of vanillin was observed highest in PEG-400 (4.29 × 10−1 at 298 K) followed by Transcutol, EA, butanol-2, ethanol, EG, PG, IPA, butanol-1 and water from T = (298–318) K. The results of thermodynamic function in terms of dissolution enthalpy, Gibbs energy and dissolution entropy showed endothermic, spontaneous and entropy-driven dissolution of vanillin in all environmentally benign solvents.