Protective effect of Funalia trogii crude extract on deltamethrin-induced oxidative stress in rats

In this study the protective effects of cold buffer extract of Funalia trogii ATCC 200800 (FtE) and vitamin E (VitE) on oxidative stress induced with deltamethrin using oral administration in rats were investigated. Deltamethrin treatment caused an increase in liver enzyme activities of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) (p < 0.05); however, it caused a decrease in activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione reductase (GRd) when compared to control group (p < 0.05). Activities of AST, ALT, ALP enzymes and level of thiobarbituric acid reactive substances (TBARS) decreased significantly after VitE administration (p < 0.05). Both enzyme activities and TBARS levels were found similar in VitE and FtE treated rats shortly after pesticide administration (p < 0.05). In conclusion, it appears that FtE prepared in cold buffer has capability to prevent the liver damage like VitE against the toxic effect of deltamethrin.

Research highlights
► The post-treatment with vitamin E and with cold water extract of Funalia trogii separately after deltamethrin administration prevented liver injury.
► Treatment with cold water extract of F. trogii shortly after deltamethrin treatment leads to a significant revival of the oxidative status, like VitE.
► Antioxidant or free radical removing action of F. trogii extract played an important role in reducing the toxicity and preserving liver membrane integrity in rats treated with deltamethrin.