کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1184867 1492150 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Polyphenolic pattern and in vitro cardioprotective properties of typical red wines from vineyards cultivated in Scafati (Salerno, Italy)
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Polyphenolic pattern and in vitro cardioprotective properties of typical red wines from vineyards cultivated in Scafati (Salerno, Italy)
چکیده انگلیسی

Wines are the subject of increasing numbers of investigations owing to the pharmaceutical usefulness of grape phytochemicals. The aim of the present work was to hypothesize the use of lyophilised red wines for the formulation of food supplements potentially useful against both physiological and induced cardiac oxidative stress. Cardiac derived H9C2 myocytes were incubated with increasing doses (0.01–1 μg) of lyophilised Aglianico wine (lioAW). Experiments showed an appreciable direct radical scavenging activity at a maximum lioAW dose of 0.03 μg that made the caspase-3 activity decrease by about 41%. Cardiac cells were exposed to 1 μM doxorubicin and its combination with different doses of lioAW. Maximum lioAW aliquot of 0.03 μg seemed to effectively contrast the induced oxidant injury decreasing the reactive oxygen species (ROSs) levels by about 38%and depressing the caspase-3 activity by about 63%. In both assays, pro-oxidant effects at higher lioAW concentrations were detected.


► Lyophilised Aglianico wine (lioAW) was tested on H9C2 cardiomyocytes.
► A good radical scavenging activity at a maximum lioAW dose of 0.03 μg was detected.
► Maximum lioAW aliquot of 0.03 μg contrasted doxorubicin induced oxidant injury.
► Pro-oxidant effects at higher lioAW concentrations were detected in all assays.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Chemistry - Volume 140, Issue 4, 15 October 2013, Pages 803–809
نویسندگان
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