کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1185489 963408 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention
چکیده انگلیسی

Kaempferol is a polyphenol antioxidant found in fruits and vegetables. Many studies have described the beneficial effects of dietary kaempferol in reducing the risk of chronic diseases, especially cancer. Epidemiological studies have shown an inverse relationship between kaempferol intake and cancer. Kaempferol may help by augmenting the body’s antioxidant defence against free radicals, which promote the development of cancer. At the molecular level, kaempferol has been reported to modulate a number of key elements in cellular signal transduction pathways linked to apoptosis, angiogenesis, inflammation, and metastasis. Significantly, kaempferol inhibits cancer cell growth and angiogenesis and induces cancer cell apoptosis, but on the other hand, kaempferol appears to preserve normal cell viability, in some cases exerting a protective effect. The aim of this review is to synthesize information concerning the extraction of kaempferol, as well as to provide insights into the molecular basis of its potential chemo-preventative activities, with an emphasis on its ability to control intracellular signaling cascades that regulate the aforementioned processes. Chemoprevention using nanotechnology to improve the bioavailability of kaempferol is also discussed.


► Kaempferol reduces the risk of chronic diseases, especially cancer.
► Kaempferol augments human body’s antioxidant defence against free radicals.
► Kaempferol modulates apoptosis, angiogenesis, inflammation, and metastasis.
► Nanotechnology can improve the bioavailability of kaempferol.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Chemistry - Volume 138, Issue 4, 15 June 2013, Pages 2099–2107
نویسندگان
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