کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1187071 | 963455 | 2008 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Influence of anthocyanins and derivative pigments from blueberry (Vaccinium myrtillus) extracts on MPP+ intestinal uptake: A structure–activity approach Influence of anthocyanins and derivative pigments from blueberry (Vaccinium myrtillus) extracts on MPP+ intestinal uptake: A structure–activity approach](/preview/png/1187071.png)
The aim of the present study was to investigate the influence of an anthocyanin extract (extract I), and two other derivative extracts (extracts II and III), which are being developed aiming to be further applied in the food industry, on intestinal uptake of organic cations. For this purpose, the effect of these compounds on 3H-MPP+ uptake was evaluated in Caco-2 cells (an enterocyte-like cell line derived from a human colonic adenocarcinoma).Extracts I and III did not present any effect on 3H-MPP+ uptake. Extract II, an anthocyanin–pyruvic acid adduct extract, decreased organic cation uptake. Some phenolic molecules were also tested, aiming to study possible structural features responsible for these effects. The results are compatible with the hypothesis of phenolic molecules bearing a carboxylic group with extended electronic conjugation being the responsible feature for the inhibitory effect on 3H-MPP+ uptake.The use of these compounds in foodstuffs must be carefully assessed since interactions with organic cations present in the diet, as nutrients or xenobiotics, may affect their absorption and bioavailability. Type and complexity of the ingested compounds are important factors in this regard, and should be taken into consideration.
Journal: Food Chemistry - Volume 109, Issue 3, 1 August 2008, Pages 587–594