کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1188265 | 963484 | 2009 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Biological evaluations of novel vitamin C esters as mushroom tyrosinase inhibitors and antioxidants Biological evaluations of novel vitamin C esters as mushroom tyrosinase inhibitors and antioxidants](/preview/png/1188265.png)
The inhibitory effects of vitamin C esters 1 and 2 on the diphenolase activity of mushroom tyrosinase have been studied. The results showed that compounds 1 and 2 inhibited tyrosinase with IC50 values of 0.58 and 0.16 mM, respectively. The dose–response curves demonstrated that compounds 1 and 2 not only lengthened the lag time, but also decreased the steady-state rate. The kinetic analyses showed that the inhibition by compound 2 was reversible and its mechanism was mixed type, which was different from compound 1 (irreversible inhibitor). Furthermore, the antioxidant activities of these compounds against hydroxyl radical scavenging, superoxide anion radical scavenging, and DPPH radical scavenging were also investigated. Compounds 1 and 2 exhibited potential antioxidant activities. In particular, compound 2 was found to be the most effective antioxidant, more potent than the well-known antioxidants vitamin C and TBHQ.
Journal: Food Chemistry - Volume 117, Issue 3, 1 December 2009, Pages 381–386