کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1193764 | 1492349 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Phenotypic analysis of Atlantic cod hemoglobin chains using a combination of top-down and bottom-up mass spectrometric approaches
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کلمات کلیدی
ESICIDFT ICR MSCollision-induced dissociation - اختلاف ناشی از برخوردAtlantic cod - اقیانوس اطلسAmino acid sequence - توالی آمینو اسیدmatrix-assisted laser desorption/ionization - جذب / یونیزاسیون لیزر ماتریس کمک می کندMass spectrometry - طیف سنجی جرمیMALDI - مالدیHemoglobin - هموگلوبینPolymorphism - پلی مورفیسمelectrospray ionization - یونیزاسیون الکترو اسپری
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Phenotypic analysis of Atlantic cod hemoglobin chains using a combination of top-down and bottom-up mass spectrometric approaches Phenotypic analysis of Atlantic cod hemoglobin chains using a combination of top-down and bottom-up mass spectrometric approaches](/preview/png/1193764.png)
چکیده انگلیسی
Amino acid sequence information of both α- and β-chains of hemoglobin collected from Atlantic cod was obtained using a combination of mass spectrometry-based top-down and bottom-up approaches. Although complete sequencing is a very challenging undertaking due to the high degree of phenotypic variation, we were able to obtain between 38%, 28%, 46%, and 18% sequence coverage for the α-1-globin, α-2-globin, β-1-globin, and β-2-globin, respectively. The results of this work provide some evidence that the hemoglobin of Atlantic cod caught off the New England shoreline in the United States show genotypic/phenotypic variation from the hemoglobin of the same species caught off the coast of Norway. Though full coverage of the sequences was not accomplished, this work demonstrates the importance of further study to catalog the phenotypic variation of the American populations of Atlantic cod.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Mass Spectrometry - Volume 278, Issues 2â3, 1 December 2008, Pages 114-121
Journal: International Journal of Mass Spectrometry - Volume 278, Issues 2â3, 1 December 2008, Pages 114-121
نویسندگان
Wendell P. Griffith, Igor A. Kaltashov,