کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1211800 | 1494030 | 2016 | 7 صفحه PDF | دانلود رایگان |
• Ayurvedic herbaceous exhibit strong cytotoxic effects against tumor cell line.
• Leaves n-butannolic fraction, exhibited the highest antiproliferatif activity.
• RP-HPLC was developed, high peak area was detected at 3.65 min.
• GC–MS was performed to identify and quantify siloxanes from n-butannolic fraction.
In the present study, the potential effect anti tumor and the chemical composition of different fractions of Gokshur was evaluated. Commonly known as puncture vine, it has been used for a long time in both the Indian and traditional Chinese medicine. It is popularly used as a remedy for fertility disorder in Ayurveda. Samples were collected during June–September 2014 in the Cap Bon (north east of the northern Tunisia). Different organs were separated and extracted by sequential process to compare and investigate their potential anti-tumor effect. For the first time, we report the antiproliferatif effect of leaves n-butannolic fraction against cancer cell lines. The better anti-tumor fraction (94.76 ± 1.52%) has been detected and performed by RP-HPLC has shown a great peak area (5578.21 Mau). Novel designed natural derivatives from Gokshur, a cyclotrisiloxane, major compound identified by GC–MS.
Journal: Journal of Chromatography B - Volume 1026, 15 July 2016, Pages 279–285