کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1211872 | 1494024 | 2016 | 5 صفحه PDF | دانلود رایگان |
• Successful trouble-shooting for an interesting and unusual stability case.
• Analyte instability in neat solutions only at high concentrations, not at lower ones.
• Stable-isotope labeled internal standard did not have the similar stability issue.
• Generally applicable insights provided for avoiding neat solution stability issues.
This paper presents the trouble-shooting for a very unusual stability case. Tetracaine was found unstable in neat solutions only at high concentrations, but not at low concentrations. Moreover, its stable-isotope labeled internal standard did not show similar behavior. A series of trouble-shooting experiments were conducted to uncover the root cause. Some generally applicable precautions/insights can be drawn from this investigation to avoid potential stability issues during bioanalytical method development and validation.
Journal: Journal of Chromatography B - Volumes 1033–1034, 15 October 2016, Pages 112–116