کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1213091 1494109 2013 26 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clinical applications of fast liquid chromatography: A review on the analysis of cardiovascular drugs and their metabolites
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Clinical applications of fast liquid chromatography: A review on the analysis of cardiovascular drugs and their metabolites
چکیده انگلیسی

One of the major challenges facing the medicine today is developing new therapies that enhance human health. To help address these challenges the utilization of analytical technologies and high-throughput automated platforms has been employed; in order to perform more experiments in a shorter time frame with increased data quality. In the last decade various analytical strategies have been established to enhance separation speed and efficiency in liquid chromatography applications. Liquid chromatography is an increasingly important tool for monitoring drugs and their metabolites. Furthermore, liquid chromatography has played an important role in pharmacokinetics and metabolism studies at these drug development stages since its introduction. This paper provides an overview of current trends in fast chromatography for the analysis of cardiovascular drugs and their metabolites in clinical applications. Current trends in fast liquid chromatographic separations involve monolith technologies, fused-core columns, high-temperature liquid chromatography (HTLC) and ultra-high performance liquid chromatography (UHPLC). The high specificity in combination with high sensitivity makes it an attractive complementary method to traditional methodology used for routine applications. The practical aspects of, recent developments in and the present status of fast chromatography for the analysis of biological fluids for therapeutic drug and metabolite monitoring, pharmacokinetic studies and bioequivalence studies are presented.


► Review was aimed at presenting of the progress in methods for the drug analysis.
► Trends in fast liquid chromatographic were described.
► Liquid chromatography is an important tool for monitoring drugs and metabolites.
► Sample preparation, column types, mobile phases, types of detection are discussed.
► Advantages of modern fast liquid chromatography methods in clinical application.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography B - Volume 927, 15 May 2013, Pages 54–79
نویسندگان
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