Ultrahigh pressure extraction of lignan compounds from Dysosma versipellis and purification by high-speed counter-current chromatography

► To extract and purify lignans from Dysosna versipellis. ► Ultrahigh pressure extraction combined with HSCCC was applied. ► Two compounds with high purities were obtained with high yield. ► The method was very useful for the extraction and purification of podophyllotoxins.