کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1213412 | 1494143 | 2011 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A new strategy for ionization enhancement by derivatization for mass spectrometry A new strategy for ionization enhancement by derivatization for mass spectrometry](/preview/png/1213412.png)
Liquid chromatography–mass spectrometry (LC–MS) using atmospheric pressure ionization is drastically different from hitherto available analytical methods used to detect polar analytes. The electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) sources of MS have contributed to the advancement of LC–MS and LC–MS/MS techniques for the analysis of biological samples. However, one major obstacle is the weak ionization of some analytes in the ESI and APCI techniques. In this review, we introduce high-sensitivity methods using several derivatization reagents for ionization enhancement. We also present an overview of chemical derivatization methods that have been applied to small molecules, such as amino acids and steroids, in biological samples.
Journal: Journal of Chromatography B - Volume 879, Issues 17–18, 15 May 2011, Pages 1159–1165