کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1214376 | 966930 | 2011 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hb Riesa or β93 (F9) Cys â Ser, a new electrophoretically silent haemoglobin variant interfering with haemoglobin A1c measurement
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
A new β variant was found in a German diabetic patient whose blood samples appeared to contain 45% Hb A1c using Bio-Rad Variant V-II A1c-analyzer but 7.6% on boronate affinity chromatography. Structural studies using, HPLC, mass spectrometry, and the genomic DNA analysis revealed a new substitution in which the cysteine residue at position β93 was replaced by serine. The variant was named Hb Riesa or β93 (F9) Cys â Ser and accounted for 54.3% of the total haemoglobin. This suggests that the protein-synthesis processes for the mutant could be slightly more promoted than those of the wild-type. Hb Riesa is clinically and electrophoretically silent.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography B - Volume 879, Issue 28, 15 October 2011, Pages 2952-2956
Journal: Journal of Chromatography B - Volume 879, Issue 28, 15 October 2011, Pages 2952-2956
نویسندگان
Emmanuel Bissé, Agnès Hovasse, Sabine Preisler-Adams, Thomas Epting, Oswald Wagner, Gabriele Kögel, Alain Van Dorsselaer, Christine Schaeffer-Reiss,