کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1214376 966930 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hb Riesa or β93 (F9) Cys → Ser, a new electrophoretically silent haemoglobin variant interfering with haemoglobin A1c measurement
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Hb Riesa or β93 (F9) Cys → Ser, a new electrophoretically silent haemoglobin variant interfering with haemoglobin A1c measurement
چکیده انگلیسی
A new β variant was found in a German diabetic patient whose blood samples appeared to contain 45% Hb A1c using Bio-Rad Variant V-II A1c-analyzer but 7.6% on boronate affinity chromatography. Structural studies using, HPLC, mass spectrometry, and the genomic DNA analysis revealed a new substitution in which the cysteine residue at position β93 was replaced by serine. The variant was named Hb Riesa or β93 (F9) Cys → Ser and accounted for 54.3% of the total haemoglobin. This suggests that the protein-synthesis processes for the mutant could be slightly more promoted than those of the wild-type. Hb Riesa is clinically and electrophoretically silent.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography B - Volume 879, Issue 28, 15 October 2011, Pages 2952-2956
نویسندگان
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