RETRACTED: Development and validation of an LC–MS method with electrospray ionization for quantitation of digoxin in human plasma and urine: Application to a pharmacokinetic study

This article has been retracted at the request of the Editors and Authors. Please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy).Reason: The method described in this paper is exclusively an intellectual property of the Dr. Margarete Fischer-Bosch, Institute of Clinical Pharmacology, Stuttgart, Germany and has been published already in two papers on pharmacokinetics of digoxin (1. Becquemont L, Glaeser H, Drescher S, Hitzl M, Simon N, Murdter TE, Heinkele G, Hofmann U, Schaefer C, Burk O, Verstuyft C, Eichelbaum M, Fromm MF. Effects of ursodeoxycholic acid on P-glycoprotein and cytochrome P450 3A4-dependent pharmacokinetics in humans. Clin. Pharmacol. Ther., 79 (2006) 449–460; and 2. Igel S, Drescher S, Mürdter T, Hofmann U, Heinkele G, Tegude H, Glaeser H, Brenner SS, Somogyi AA, Omari T, Schäfer C, Eichelbaum M, Fromm MF. Increased absorption of digoxin from the human jejunum due to inhibition of intestinal transporter-mediated efflux. Clin. Pharmacokinet., 46 (2007) 777–785).